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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Based on several years of detailed research into the architectural consequences of construction when exposed to industrialised production techniques and systems, Architectural System Structures represents a new way to look at what is already there and is useful for all those interested in the processes of architectural creation and realisation specifically attached to time, place and cultural context.


Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. It establishes the idea of a systems view on buildings and architectural design that through the use of flexible constituent elements facilitates discussion and decision making about how architectural wholes are appropriately put together as assemblages of what the current and future building industry is capable of producing.



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  1. Also acts as a coactivator of androgen receptor ANDR -dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression.

  2. Required for gastrulation during embryogenesis.

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